A sign marks an entrance to Saint Thomas Hospital medical campus in Nashville, Tenn., on Wednesday, Oct. 3, 2012. An outbreak of a rare and deadly form of meningitis that has sickened more than two dozen people was first detected among patients treated at the Saint Thomas Outpatient Neurosurgery Center in the complex. (AP Photo/Erik Schelzig)
A sign marks an entrance to Saint Thomas Hospital medical campus in Nashville, Tenn., on Wednesday, Oct. 3, 2012. An outbreak of a rare and deadly form of meningitis that has sickened more than two dozen people was first detected among patients treated at the Saint Thomas Outpatient Neurosurgery Center in the complex. (AP Photo/Erik Schelzig)
In this Tuesday, Oct. 2, 2012 photo, Dr. David Reagan, chief medical officer for the Tennessee Department of Health, right, and Dr. Marion Kayiner, also with the state health department tell local and national media about an outbreak of fungal meningitis infections that have already killed two and sickened 13 others in Nashville, Tenn. (AP Photo/The Tennessean, Shelley Mays) NO SALES
In this Tuesday, Oct. 2, 2012 photo, Dr. David Reagan, chief medical officer for the Tennessee Department of Health,center, and Dr. Marion Kayiner talks with local and national media about an outbreak of fungal meningitis infections that have already killed two and sickened 13 others in Nashville, Tenn. (AP Photo/The Tennessean, Shelley Mays) NO SALES
The Saint Thomas Medical Plaza building is seen in Nashville, Tenn., on Wednesday, Oct. 3, 2012. An outbreak of a rare and deadly form of meningitis that has sickened more than two dozen people was first detected among patients treated at the Saint Thomas Outpatient Neurosurgery Center located in the building. (AP Photo/Erik Schelzig)
NASHVILLE, Tenn. (AP) ? An outbreak of a rare and deadly form of meningitis has now sickened 26 people in five states who received steroid injections mostly for back pain, health officials said Wednesday. Four people have died, and more cases are expected.
Eighteen cases of fungal meningitis are in Tennessee where a Nashville clinic received the largest shipment of the steroid suspected in the outbreak. The drug was made by a specialty pharmacy in Massachusetts that issued a recall last week. Investigators, though, say they are still trying to confirm the source of the infections.
Three cases have been reported in Virginia, two in Maryland, two in Florida and one in North Carolina. Two of the deaths were in Tennessee; Virginia and Maryland had one each, the Centers for Disease Control and Prevention.
More new cases are almost certain to appear in the coming days, said Tennessee Department of Health Commissioner John Dreyzehner. Five new cases were confirmed over the past 24 hours, he said Wednesday, calling the situation a "rapidly evolving outbreak."
But federal health officials weren't clear about whether new infections are occurring. They are looking for ? and increasingly finding ? illnesses that occurred in the last two or three months.
Meningitis is caused by the inflammation of meninges, which are protective membranes covering the brain and spinal cord.
Officials say this type of fungal meningitis is caused by a common fungus often found in leaf mold. It doesn't normally cause disease in healthy people. Fungal meningitis is not contagious like the more common viral and bacterial meningitis.
Symptoms include worsening and severe headache, nausea, dizziness and fever. Some of the patients in Tennessee also experienced slurred speech, and difficulty walking and urinating, Tennessee health officials said.
"Some are doing well and improving. Some are very ill ? very, very seriously ill and may die," Dr. David Reagan, a Tennessee health official said of the state's patients.
The incubation period is estimated at anywhere from 2 to 28 days, so some people may not have fallen ill yet, Tennessee health officials said. At three clinics in Tennessee, officials are contacting the more than 900 people who received the steroid in the past three months
Investigators have been looking into the antiseptic and anesthetic used during the injections. Neither has been ruled out. However, the primary suspicion is on the steroid medication. Steroid shots are common for back pain, often given together with an anesthetic.
The Food and Drug Administration identified the maker of the steroid as New England Compounding Center, a specialty pharmacy in Framingham, Mass. Last week, the company issued a recall of three lots of the steroid ? methylprednisolone acetate. In a statement, the company said it had voluntarily suspended operations and was working with regulators to identify the source of the infection.
The outbreak was discovered about two weeks ago when Vanderbilt University's Dr. April Pettit was treating a patient who was not doing well for reasons doctors did not understand.
When the laboratory found the fungus in the patient's spinal fluid, Pettit began asking questions and learned the patient recently had steroid injections in his spine, according to Dr. William Schaffner, who chairs Vanderbilt's Department of Preventive Medicine.
"When it became clear that the infection control practices at the clinic were up to par, the steroid medication became implicated," Schaffner said.
Federal officials did not release condition reports or details on all the patients in the five states. Fungal meningitis is treated with high-dose antifungal medications, usually given intravenously in a hospital.
Seventeen of the Tennessee cases were treated at the Saint Thomas Outpatient Neurosurgery Center in Nashville. It had 2,000 vials of the suspect lots, the largest number. That clinic voluntarily closed last month to deal with the investigation.
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Stobbe reported from New York.
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Online:
CDC: http://www.cdc.gov/meningitis/fungal.html
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